The human intestinal tract contains seven enzymes which split dietary disaccharides into free monosaccharides. Up until now, commercially available enzyme products contained enzyme ingredients which had the activity of only some of these disaccharidase enzymes. One in particular, however, sucrase-isomaltase complex was only partially represented in these products. Invertase is present in these available products to hydrolyze sucrose to yield glucose and fructose, and to hydrolyze other complex sugars that contain fructose, so it acts as a sucrase enzyme. The isomaltase fraction of that human enzyme is not represented because there is no commercially available form of isomaltase available in the world.
The importance of this missing enzyme fraction was confirmed in January 2004 by R. Kushak, Ph. D. and T. Buie, MD of Massachusetts General Children’s Hospital in an intestinal biopsy study involving 100 special needs children. The study showed that 60% of these patients had weak lactase activity and 25-45% had weak isomaltase/palatinase activity, which evidenced their special dietary need for an enzyme providing isomaltase/palatinase activity.
This study provided the impetus for Kirkman to search for an enzyme which had the isomaltase/palatinase type activity. Kirkman found that enzyme and trademarked it Isogest.® Isogest® has the ability to split isomaltose into two molecules of glucose, and to split palatinose into one molecule of glucose and one molecule of fructose. The result of the inclusion of this new enzyme is better, more complete carbohydrate digestion. Currently, no other enzyme product can offer this added activity.
Enzyme Complete II is Kirkman’s second generation version of Enzyme Complete/DPPIV. It contains all the enzymes present in Enzyme Complete/DPPIV plus Isogest®. The presence of Isogest® gives Enzyme Complete II the equivalent activity of the Isomaltase fraction of the sucrase/isomaltase enzyme found in the human digestive system.
Individuals currently using Enzyme Complete/DPPIV that are getting partial results which still need some improvement or individuals using other available enzymes who are not completely satisfied with the results should try Enzyme Complete II with Isogest.®
Doctors and parents who participated in the clinical evaluations of Kirkman products containing Isogest® reported the following summary of benefits:
- Less bloating
- More regular bowel habits
- Less constipation
- More normal stools
- Better overall digestion with less discomfort
- Firmer stools
- Less gas
- Less diarrhea
- Less sensitivity to dairy and grains
- Less odorous bowel movements
Participating clinicians reported no significant undesirable side effects from the revolutionary new product.
1-2 capsules at the beginning of meals or as directed by your health care practitioner.